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How long does it take for cefuroxime to work? It is usually taken every 12 hours for 5-10 days, depending on the condition being treated. To treat gonorrhea, cefuroxime is taken as a single dose, and to treat Lyme disease, cefuroxime is taken every 12 hours for 20 days. Take the suspension with food; the tablet may be taken with or without food.
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